TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor progression. However, regulation of CSCs stemness is not entirely understood. Here, we report that TSPAN8 expression is upregulated in breast CSCs, promotes the expression of the stemness gene NANOG, OCT4, and ALDHA1...

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Detalles Bibliográficos
Autores principales: Zhu, Rongxuan, Gires, Olivier, Zhu, Liqun, Liu, Jun, Li, Junjian, Yang, Hao, Ju, Gaoda, Huang, Jing, Ge, Weiyu, Chen, Yi, Lu, Zhimin, Wang, Hongxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599078/
https://www.ncbi.nlm.nih.gov/pubmed/31253779
http://dx.doi.org/10.1038/s41467-019-10739-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599078/
https://www.ncbi.nlm.nih.gov/pubmed/31253779
http://dx.doi.org/10.1038/s41467-019-10739-3

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