Cargando…

Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation

Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorders (ASDs) in human genetic studies. Here we found that chemogenetic activation of pyramidal neurons in the prefrontal cortex (PFC) of Shank3-deficient mice with the hM3D (Gq) DREADD restored social preference behavior...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Luye, Ma, Kaijie, Yan, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599088/ https://www.ncbi.nlm.nih.gov/pubmed/31247448 http://dx.doi.org/10.1016/j.isci.2019.06.014

Ejemplares similares

Social Deficits in Shank3-deficient Mouse Models of Autism Are Rescued by histone deacetylase (HDAC) Inhibition
por: Qin, Luye, et al.
Publicado: (2018)

Top-Down Suppression of Sensory Cortex in an NMDAR Hypofunction Model of Psychosis
por: Ranson, Adam, et al.
Publicado: (2019)

NMDAR Hypofunction Animal Models of Schizophrenia
por: Lee, Gloria, et al.
Publicado: (2019)

Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats
por: Jacot-Descombes, Sarah, et al.
Publicado: (2020)

Drugs Based on NMDAR Hypofunction Hypothesis in Schizophrenia
por: Wu, Qiongqiong, et al.
Publicado: (2021)

Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures
por: Qin, Luye, et al.
Publicado: (2021)

Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model
por: Williams, Jamal B., et al.
Publicado: (2023)

Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex
por: Rocchi, Federico, et al.
Publicado: (2022)

Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates
por: Upright, Nicholas A., et al.
Publicado: (2020)

Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment
por: Seshadri, Saurav, et al.
Publicado: (2018)

Aberrant maturation and connectivity of prefrontal cortex in schizophrenia – contribution of NMDA receptor development and hypofunction
por: Gao, Wen-Jun, et al.
Publicado: (2022)

GABA(B)-mediated rescue of altered excitatory–inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction
por: Gandal, M J, et al.
Publicado: (2012)

Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption
por: McEown, Kristopher, et al.
Publicado: (2016)

Chemogenetic activation of the perirhinal cortex reverses methamphetamine-induced memory deficits and reduces relapse
por: Peters, Jamie, et al.
Publicado: (2018)

Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABAergic Parvalbumin Interneurons Attenuates the Impact of Chronic Stress in Male Mice
por: Nawreen, Nawshaba, et al.
Publicado: (2020)

Chemogenetic Activation of Astrocytes in the Basolateral Amygdala Contributes to Fear Memory Formation by Modulating the Amygdala–Prefrontal Cortex Communication
por: Lei, Zhuogui, et al.
Publicado: (2022)

Optimizing clozapine for chemogenetic neuromodulation of somatosensory cortex
por: Cho, Jongwook, et al.
Publicado: (2020)

Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone
por: Delgado-Sallent, Cristina, et al.
Publicado: (2023)

Suppression of exaggerated NMDAR activity by memantine treatment ameliorates neurological and behavioral deficits in aminopeptidase P1-deficient mice
por: Bae, Young-Soo, et al.
Publicado: (2022)

Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex of Shank2-Mutant Mice
por: Lee, Seungjoon, et al.
Publicado: (2021)

Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction
por: Pittman-Polletta, Benjamin, et al.
Publicado: (2018)

NMDAR hypofunction and somatostatin-expressing GABAergic interneurons and receptors: A newly identified correlation and its effects in schizophrenia
por: Alherz, Fatemah, et al.
Publicado: (2017)

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat
por: Harony-Nicolas, Hala, et al.
Publicado: (2017)

Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice
por: Tuscher, Jennifer J., et al.
Publicado: (2018)

Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques
por: Noritake, Atsushi, et al.
Publicado: (2023)

STAT3 ameliorates cognitive deficits via regulation of NMDAR expression in an Alzheimer's disease animal model
por: Wan, Hua-Li, et al.
Publicado: (2021)

Contribution of NMDA Receptor Hypofunction in Prefrontal and Cortical Excitatory Neurons to Schizophrenia-Like Phenotypes
por: Rompala, Gregory R., et al.
Publicado: (2013)

Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis
por: Torrillas-de la Cal, Alejandro, et al.
Publicado: (2023)

Decision Making in Mice During an Optimized Touchscreen Spatial Working Memory Task Sensitive to Medial Prefrontal Cortex Inactivation and NMDA Receptor Hypofunction
por: Dexter, Tyler D., et al.
Publicado: (2022)

Restoring Shank3 in the rostral brainstem of shank3ab−/− zebrafish autism models rescues sensory deficits
por: Kozol, Robert A., et al.
Publicado: (2021)

Diminished activity-dependent BDNF signaling differentially causes autism-like behavioral deficits in male and female mice
por: Ma, Kaijie, et al.
Publicado: (2023)

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17
por: Hong, Xiao-Yue, et al.
Publicado: (2020)

Chemogenetic stimulation of the infralimbic cortex reverses alcohol-induced fear memory overgeneralization
por: Scarlata, M. J., et al.
Publicado: (2019)

Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits
por: Rapanelli, Maximiliano, et al.
Publicado: (2023)

Behavioral and Sensory Deficits Associated with Dysfunction of GABAergic System in a Novel shank2-Deficient Zebrafish Model
por: Wang, Yi, et al.
Publicado: (2023)

Chemogenetic inhibition of prefrontal projection neurons constrain top-down control of attention in young but not aged rats
por: Duggan, Michael R., et al.
Publicado: (2021)

Disassembly of Shank and Homer Synaptic Clusters Is Driven by Soluble β-Amyloid(1-40) through Divergent NMDAR-Dependent Signalling Pathways
por: Roselli, Francesco, et al.
Publicado: (2009)

Ketamine, but Not the NMDAR Antagonist Lanicemine, Increases Prefrontal Global Connectivity in Depressed Patients
por: Abdallah, Chadi G., et al.
Publicado: (2018)

Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats
por: Hasan, Mahadi, et al.
Publicado: (2022)

Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats
por: Hasan, Mahadi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3k0k09pl9gbjruhkc472434p13