Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation

Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorders (ASDs) in human genetic studies. Here we found that chemogenetic activation of pyramidal neurons in the prefrontal cortex (PFC) of Shank3-deficient mice with the hM3D (Gq) DREADD restored social preference behavior...

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Detalles Bibliográficos
Autores principales: Qin, Luye, Ma, Kaijie, Yan, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599088/
https://www.ncbi.nlm.nih.gov/pubmed/31247448
http://dx.doi.org/10.1016/j.isci.2019.06.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599088/
https://www.ncbi.nlm.nih.gov/pubmed/31247448
http://dx.doi.org/10.1016/j.isci.2019.06.014

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