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Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein
Cell-to-cell transmission of toxic forms of α-Synuclein (αS) is thought to underlie disease progression in Parkinson disease. αS in humans is constitutively N-terminally acetylated (αS(acetyl)), although the impact of this modification is relatively unexplored. Here, we report that αS(acetyl) is mor...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599126/ https://www.ncbi.nlm.nih.gov/pubmed/31211781 http://dx.doi.org/10.1371/journal.pbio.3000318 |