Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia

INTRODUCTION: The chromosomal rearrangements of the mixed-lineage leukemia gene MLL (KMT2A) have been extensively characterized as a potent oncogenic driver in leukemia. For its oncogenic function, most MLL-fusion proteins exploit the multienzyme super elongation complex leading to elevated expressi...

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Detalles Bibliográficos
Autores principales: Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Steckel, Michael, Eheim, Ashley L., Haegebarth, Andrea, Stresemann, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599250/
https://www.ncbi.nlm.nih.gov/pubmed/31253180
http://dx.doi.org/10.1186/s13045-019-0749-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599250/
https://www.ncbi.nlm.nih.gov/pubmed/31253180
http://dx.doi.org/10.1186/s13045-019-0749-y

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