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Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia

INTRODUCTION: The chromosomal rearrangements of the mixed-lineage leukemia gene MLL (KMT2A) have been extensively characterized as a potent oncogenic driver in leukemia. For its oncogenic function, most MLL-fusion proteins exploit the multienzyme super elongation complex leading to elevated expressi...

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Detalles Bibliográficos
Autores principales:	Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Steckel, Michael, Eheim, Ashley L., Haegebarth, Andrea, Stresemann, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599250/ https://www.ncbi.nlm.nih.gov/pubmed/31253180 http://dx.doi.org/10.1186/s13045-019-0749-y

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