Prostaglandin receptor EP4 expression by Th17 cells is associated with high disease activity in ankylosing spondylitis

BACKGROUND: Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS). However, the mechanism underlying enhanced Th17 cell accumulation in AS remains unknown. The prostaglandin E(2) receptor EP2/EP4 signaling pathway plays a critical role in the development of autoimmune Th17 cells...

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Detalles Bibliográficos
Autores principales: Klasen, Charlotte, Meyer, Anja, Wittekind, Paula S., Waqué, Iris, Nabhani, Schafiq, Kofler, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599260/
https://www.ncbi.nlm.nih.gov/pubmed/31253169
http://dx.doi.org/10.1186/s13075-019-1948-1

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