Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling

Background: Liver fibrosis is characterized by extensive deposition of extracellular matrix (ECM) components in the liver. RCAN1 (regulator of calcineurin 1), an endogenous inhibitor of calcineurin (CaN), is required for ECM synthesis during hypertrophy of various organs. However, the functional rol...

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Detalles Bibliográficos
Autores principales: Pan, Xue-yin, You, Hong-mei, Wang, Ling, Bi, Yi-hui, Yang, Yang, Meng, Hong-wu, Meng, Xiao-ming, Ma, Tao-tao, Huang, Cheng, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599664/
https://www.ncbi.nlm.nih.gov/pubmed/31285763
http://dx.doi.org/10.7150/thno.32710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599664/
https://www.ncbi.nlm.nih.gov/pubmed/31285763
http://dx.doi.org/10.7150/thno.32710

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