Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening

As part of an effort to identify druggable diacylglycerol kinase alpha (DGKα) inhibitors, we used an insilico approach based on chemical homology with the two commercially available DGKα inhibitors R59022 and R59949. Ritanserin and compound AMB639752 emerged from the screening of 127 compounds, show...

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Detalles Bibliográficos
Autores principales: Velnati, Suresh, Ruffo, Elisa, Massarotti, Alberto, Talmon, Maria, Varma, Konduru Sai Sandeep, Gesu, Alessandro, Fresu, Luigia Grazia, Snow, Andrew L., Bertoni, Alessandra, Capello, Daniela, Tron, Gian Cesare, Graziani, Andrea, Baldanzi, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599760/
https://www.ncbi.nlm.nih.gov/pubmed/30611057
http://dx.doi.org/10.1016/j.ejmech.2018.12.061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599760/
https://www.ncbi.nlm.nih.gov/pubmed/30611057
http://dx.doi.org/10.1016/j.ejmech.2018.12.061

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