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Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening
As part of an effort to identify druggable diacylglycerol kinase alpha (DGKα) inhibitors, we used an insilico approach based on chemical homology with the two commercially available DGKα inhibitors R59022 and R59949. Ritanserin and compound AMB639752 emerged from the screening of 127 compounds, show...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599760/ https://www.ncbi.nlm.nih.gov/pubmed/30611057 http://dx.doi.org/10.1016/j.ejmech.2018.12.061 |