A Type III CRISPR Ancillary Ribonuclease Degrades Its Cyclic Oligoadenylate Activator

Cyclic oligoadenylate (cOA) secondary messengers are generated by type III CRISPR systems in response to viral infection. cOA allosterically activates the CRISPR ancillary ribonucleases Csx1/Csm6, which degrade RNA non-specifically using a HEPN (Higher Eukaryotes and Prokaryotes, Nucleotide binding)...

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Detalles Bibliográficos
Autores principales: Athukoralage, Januka S., Graham, Shirley, Grüschow, Sabine, Rouillon, Christophe, White, Malcolm F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599890/
https://www.ncbi.nlm.nih.gov/pubmed/31071326
http://dx.doi.org/10.1016/j.jmb.2019.04.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599890/
https://www.ncbi.nlm.nih.gov/pubmed/31071326
http://dx.doi.org/10.1016/j.jmb.2019.04.041

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