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Identification of an Alternating-Access Dynamics Mutant of EmrE with Impaired Transport
Proteins that perform active transport must alternate the access of a binding site, first to one side of a membrane and then to the other, resulting in the transport of bound substrates across the membrane. To better understand this process, we sought to identify mutants of the small multidrug resis...
Autores principales: | Wu, Chao, Wynne, Samantha A., Thomas, Nathan E., Uhlemann, Eva-Maria, Tate, Christopher G., Henzler-Wildman, Katherine A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599891/ https://www.ncbi.nlm.nih.gov/pubmed/31158365 http://dx.doi.org/10.1016/j.jmb.2019.05.035 |
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