Ferumoxytol and CpG oligodeoxynucleotide 2395 synergistically enhance antitumor activity of macrophages against NSCLC with EGFR(L858R/T790M) mutation

Purpose: Drug resistance is a major challenge for epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) treatment of lung cancer. Ferumoxytol (FMT) drives macrophage (MΦ) transformation towards a M1-like phenotype and thereby inhibits tumor growth. CpG oligodeoxynucleotide 2395 (...

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Detalles Bibliográficos
Autores principales: Wang, Guoqun, Zhao, Jiaojiao, Zhang, Meiling, Wang, Qian, Chen, Bo, Hou, Yayi, Lu, Kaihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599896/
https://www.ncbi.nlm.nih.gov/pubmed/31417255
http://dx.doi.org/10.2147/IJN.S193583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599896/
https://www.ncbi.nlm.nih.gov/pubmed/31417255
http://dx.doi.org/10.2147/IJN.S193583

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