Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis

Shiga toxin 1 (STx1) and 2 (STx2), produced by Shiga toxin–producing Escherichia coli, cause lethal untreatable disease. The toxins invade cells via retrograde trafficking. Direct early endosome-to-Golgi transport allows the toxins to evade degradative late endosomes. Blocking toxin trafficking, par...

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Detalles Bibliográficos
Autores principales: Selyunin, Andrey S, Hutchens, Steven, McHardy, Stanton F, Mukhopadhyay, Somshuvra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599968/
https://www.ncbi.nlm.nih.gov/pubmed/31243048
http://dx.doi.org/10.26508/lsa.201900439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599968/
https://www.ncbi.nlm.nih.gov/pubmed/31243048
http://dx.doi.org/10.26508/lsa.201900439

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