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Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis

Shiga toxin 1 (STx1) and 2 (STx2), produced by Shiga toxin–producing Escherichia coli, cause lethal untreatable disease. The toxins invade cells via retrograde trafficking. Direct early endosome-to-Golgi transport allows the toxins to evade degradative late endosomes. Blocking toxin trafficking, par...

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Detalles Bibliográficos
Autores principales:	Selyunin, Andrey S, Hutchens, Steven, McHardy, Stanton F, Mukhopadhyay, Somshuvra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599968/ https://www.ncbi.nlm.nih.gov/pubmed/31243048 http://dx.doi.org/10.26508/lsa.201900439

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