Bioactive fluorenes. part I. Synthesis, pharmacological study and molecular docking of novel dihydrofolate reductase inhibitors based-2,7-dichlorofluorene

In this study, a new series of 2,7-dichloro-4-(2-substituted-amino acetyl)fluorene derivatives were synthesized, characterized and evaluated for their antimicrobial activity and screened for cytotoxic activity against human lung carcinoma (A-549) and human breast carcinoma (MCF-7) cell lines. Most o...

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Detalles Bibliográficos
Autores principales: Hussein, Essam M., Alsantali, Reem I., Abd El-Galil, Shimaa M., Obaid, Rami J., Alharbi, Ahmed, Abourehab, Mohamed A.S., Ahmed, Saleh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599973/
https://www.ncbi.nlm.nih.gov/pubmed/31304415
http://dx.doi.org/10.1016/j.heliyon.2019.e01982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599973/
https://www.ncbi.nlm.nih.gov/pubmed/31304415
http://dx.doi.org/10.1016/j.heliyon.2019.e01982

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