Inhibition of Karyopherin-α2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair

Ionizing radiation (IR) has been widely used in the treatment of cancer. Radiation-induced DNA damage triggers the DNA damage response (DDR), which can confer radioresistance and early local recurrence by activating DNA repair pathways. Since karyopherin-α2 (KPNA2), playing an important role in nucl...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Kyung-Hee, Jung, Seung-Youn, Park, Jeong-In, Ahn, Jiyeon, Park, Jong Kuk, Um, Hong-Duck, Park, In-Chul, Hwang, Sang-Gu, Ha, Hunjoo, Song, Jie-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600173/
https://www.ncbi.nlm.nih.gov/pubmed/31212646
http://dx.doi.org/10.3390/ijms20112843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600173/
https://www.ncbi.nlm.nih.gov/pubmed/31212646
http://dx.doi.org/10.3390/ijms20112843

Ejemplares similares