Cargando…

Inhibition of Karyopherin-α2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair

Ionizing radiation (IR) has been widely used in the treatment of cancer. Radiation-induced DNA damage triggers the DNA damage response (DDR), which can confer radioresistance and early local recurrence by activating DNA repair pathways. Since karyopherin-α2 (KPNA2), playing an important role in nucl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Kyung-Hee, Jung, Seung-Youn, Park, Jeong-In, Ahn, Jiyeon, Park, Jong Kuk, Um, Hong-Duck, Park, In-Chul, Hwang, Sang-Gu, Ha, Hunjoo, Song, Jie-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600173/ https://www.ncbi.nlm.nih.gov/pubmed/31212646 http://dx.doi.org/10.3390/ijms20112843

Ejemplares similares

Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models
por: Song, Kyung-Hee, et al.
Publicado: (2020)

Karyopherins play the field
por: Leslie, Mitch
Publicado: (2006)

Karyopherin abnormalities in neurodegenerative proteinopathies
por: Pasha, Terouz, et al.
Publicado: (2021)

Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer
por: Ohhara, Yoshihito, et al.
Publicado: (2022)

Low-dose γ-radiation inhibits IL-1β-induced dedifferentiation and inflammation of articular chondrocytes via blockage of catenin signaling
por: Hong, Eun-Hee, et al.
Publicado: (2014)

The role of karyopherins in the regulated sumoylation of septins
por: Makhnevych, Taras, et al.
Publicado: (2007)

Identification of Karyopherin α1 and α7 Interacting Proteins in Porcine Tissue
por: Park, Ki-Eun, et al.
Publicado: (2012)

Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation
por: Laitman, Benjamin M., et al.
Publicado: (2017)

AMRI-59 functions as a radiosensitizer via peroxiredoxin I-targeted ROS accumulation and apoptotic cell death induction
por: Hong, Wan Gi, et al.
Publicado: (2017)

Inhibition of NUPR1–Karyopherin β1 Binding Increases Anticancer Drug Sensitivity
por: Park, Chanhee, et al.
Publicado: (2021)

RIP1 Is a Novel Component of γ-ionizing Radiation-Induced Invasion of Non-Small Cell Lung Cancer Cells
por: Kang, A-Ram, et al.
Publicado: (2020)

Mitochondrial superoxide dismutase 2 mediates γ-irradiation-induced cancer cell invasion
por: Jung, Chan-Hun, et al.
Publicado: (2019)

Karyopherins regulate nuclear pore complex barrier and transport function
por: Kapinos, Larisa E., et al.
Publicado: (2017)

Inhibition of Karyopherin beta 1 suppresses prostate cancer growth
por: Yang, Jian, et al.
Publicado: (2019)

Karyopherin α deficiency contributes to human preimplantation embryo arrest
por: Wang, Wenjing, et al.
Publicado: (2023)

Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice
por: Park, Jong Hee, et al.
Publicado: (2015)

A new FGFR inhibitor disrupts the TGF‐β1‐induced fibrotic process
por: Kim, Mi‐Hyoung, et al.
Publicado: (2019)

Slug promotes p53 and p21 protein degradation by inducing Mdm2 expression in HCT116 colon cancer cells
por: Kim, Jongdoo, et al.
Publicado: (2021)

Yeast karyopherin Kap95 is required for cell cycle progression at Start
por: Taberner, Francisco José, et al.
Publicado: (2010)

Dissecting in vivo steady-state dynamics of karyopherin-dependent nuclear transport
por: Lolodi, Ogheneochukome, et al.
Publicado: (2016)

Identification of the Karyopherin Superfamily in Maize and Its Functional Cues in Plant Development
por: Jin, Lu, et al.
Publicado: (2022)

Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx
por: Baek, Jeong-Hwa, et al.
Publicado: (2018)

Conformal invariance of curvature perturbation
por: Gong, Jinn-Ouk, et al.
Publicado: (2011)

Overexpression of karyopherin-α2 in cholangiocarcinoma correlates with poor prognosis and gemcitabine sensitivity via nuclear translocation of DNA repair proteins
por: Tsukagoshi, Mariko, et al.
Publicado: (2017)

Podophyllotoxin acetate triggers anticancer effects against non-small cell lung cancer cells by promoting cell death via cell cycle arrest, ER stress and autophagy
por: CHOI, JAE YEON, et al.
Publicado: (2015)

Radiotherapy diagnostic biomarkers in radioresistant human H460 lung cancer stem-like cells
por: Yun, Hong Shik, et al.
Publicado: (2016)

Radiosensitizer Effect of β-Apopicropodophyllin against Colorectal Cancer via Induction of Reactive Oxygen Species and Apoptosis
por: Kwon, Jin-Hee, et al.
Publicado: (2021)

Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines
por: Hazawa, Masaharu, et al.
Publicado: (2020)

Involvement of SULF2 in γ-irradiation-induced invasion and resistance of cancer cells by inducing IL-6 expression
por: Jung, Chan-Hun, et al.
Publicado: (2016)

Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport
por: Huang, Hsiao-Yun, et al.
Publicado: (2014)

The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer
por: Christiansen, Anders, et al.
Publicado: (2013)

Karyopherin enrichment and compensation fortifies the nuclear pore complex against nucleocytoplasmic leakage
por: Kalita, Joanna, et al.
Publicado: (2022)

Endogenous catalase delays high-fat diet-induced liver injury in mice
por: Piao, Lingjuan, et al.
Publicado: (2017)

Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ
por: Ding, Lina, et al.
Publicado: (2019)

JNC-1043, a Novel Podophyllotoxin Derivative, Exerts Anticancer Drug and Radiosensitizer Effects in Colorectal Cancer Cells
por: Kwon, Jin-Hee, et al.
Publicado: (2022)

Establishment of animal model for the analysis of cancer cell metastasis during radiotherapy
por: Park, Jong Kuk, et al.
Publicado: (2012)

Evolution of the Karyopherin-β Family of Nucleocytoplasmic Transport Factors; Ancient Origins and Continued Specialization
por: O'Reilly, Amanda J., et al.
Publicado: (2011)

Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr
por: Ben-Efraim, Iris, et al.
Publicado: (2009)

Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients
por: Zaza, Gianluigi, et al.
Publicado: (2014)

Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes
por: Umegaki-Arao, Noriko, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_dmhvoabnnm4gr9stt4b8shsehj