RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity

Virus-derived double-stranded RNA (dsRNA) molecules containing a triphosphate group at the 5′ end are natural ligands of retinoic acid-inducible gene I (RIG-I). The cellular pathways and proteins induced by RIG-I are an essential part of the innate immune response against viral infections. Starting...

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Detalles Bibliográficos
Autores principales: Ho, Victor, Yong, Hui Yee, Chevrier, Marion, Narang, Vipin, Lum, Josephine, Toh, Ying-Xiu, Lee, Bernett, Chen, Jinmiao, Tan, Ern Yu, Luo, Dahai, Fink, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600207/
https://www.ncbi.nlm.nih.gov/pubmed/31043531
http://dx.doi.org/10.1128/JVI.00102-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600207/
https://www.ncbi.nlm.nih.gov/pubmed/31043531
http://dx.doi.org/10.1128/JVI.00102-19

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