Potent Anti-Ovarian Cancer with Inhibitor Activities on Both Topoisomerase II and (V600E)BRAF of Synthesized Substituted Estrone Candidates

A series of 16-(α-alkoxyalkane)-17-hydrazino-estra-1(10),2,4-trien[17,16-c]-3-ol (3a–l) and estra-1(10),2,4-trien-[17,16-c]pyrazoline-3-ol derivatives (4a–d) were synthesized from corresponding arylidines 2a,b which was prepared from estrone 1 as starting material. Condensation of 1 with aldehydes g...

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Detalles Bibliográficos
Autores principales: El-Naggar, Mohamed, E. Amr, Abd El-Galil, Fayed, Ahmed A., A. Elsayed, Elsayed, A. Al-Omar, Mohamed, Abdalla, Mohamed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600292/
https://www.ncbi.nlm.nih.gov/pubmed/31146483
http://dx.doi.org/10.3390/molecules24112054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600292/
https://www.ncbi.nlm.nih.gov/pubmed/31146483
http://dx.doi.org/10.3390/molecules24112054

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