Methylation Density Pattern of KEAP1 Gene in Lung Cancer Cell Lines Detected by Quantitative Methylation Specific PCR and Pyrosequencing

Background. The KEAP1/NRF2 pathway is the key regulator of antioxidants and cellular stress responses, and is implicated in neoplastic progression and resistance of tumors to treatment. KEAP1 silencing by promoter methylation is widely reported in solid tumors as part of the complex regulation of th...

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Detalles Bibliográficos
Autores principales: Fabrizio, Federico Pio, Sparaneo, Angelo, Centra, Flavia, Trombetta, Domenico, Storlazzi, Clelia Tiziana, Graziano, Paolo, Maiello, Evaristo, Fazio, Vito Michele, Muscarella, Lucia Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600322/
https://www.ncbi.nlm.nih.gov/pubmed/31159323
http://dx.doi.org/10.3390/ijms20112697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600322/
https://www.ncbi.nlm.nih.gov/pubmed/31159323
http://dx.doi.org/10.3390/ijms20112697

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