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Development of the Inhibitors That Target the PD-1/PD-L1 Interaction—A Brief Look at Progress on Small Molecules, Peptides and Macrocycles

Cancer immunotherapy based on antibodies targeting the immune checkpoint PD-1/PD-L1 pathway has seen unprecedented clinical responses and constitutes the new paradigm in cancer therapy. The antibody-based immunotherapies have several limitations such as high production cost of the antibodies or thei...

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Detalles Bibliográficos
Autores principales: Guzik, Katarzyna, Tomala, Marcin, Muszak, Damian, Konieczny, Magdalena, Hec, Aleksandra, Błaszkiewicz, Urszula, Pustuła, Marcin, Butera, Roberto, Dömling, Alexander, Holak, Tad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600339/
https://www.ncbi.nlm.nih.gov/pubmed/31151293
http://dx.doi.org/10.3390/molecules24112071