Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

Clinical studies show a significant association of childhood adversities and FK506-binding protein 5 (FKBP5) polymorphisms on increasing the susceptibility for neuropsychiatric disorders. However, the mechanisms by which early life stress (ELS) influences FKBP5 actions have not been fully elucidated...

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Detalles Bibliográficos
Autores principales: Criado-Marrero, Marangelie, Gebru, Niat T., Gould, Lauren A., Smith, Taylor M., Kim, Sojeong, Blackburn, Roy J., Dickey, Chad A., Blair, Laura J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600369/
https://www.ncbi.nlm.nih.gov/pubmed/31167373
http://dx.doi.org/10.3390/ijms20112738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600369/
https://www.ncbi.nlm.nih.gov/pubmed/31167373
http://dx.doi.org/10.3390/ijms20112738

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