Synthesis and Biological Evaluation of NH(2)-Sulfonyl Oseltamivir Analogues as Influenza Neuraminidase Inhibitors

A series of NH(2)-sulfonyl oseltamivir analogues were designed, synthesized, and their inhibitory activities against neuraminidase from H5N1 subtype evaluated. The results indicated that the IC(50) value of compound 4a, an oseltamivir analogue via methyl sulfonylation of C5-NH(2), was 3.50 μM. Molec...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Yaping, Chen, Binfeng, Lei, Zaiqiang, Zhao, Hongqian, Zhu, Hongxi, Quan, Peng, Tian, Yongshou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600469/
https://www.ncbi.nlm.nih.gov/pubmed/31185617
http://dx.doi.org/10.3390/molecules24112176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600469/
https://www.ncbi.nlm.nih.gov/pubmed/31185617
http://dx.doi.org/10.3390/molecules24112176

Ejemplares similares