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Synthesis and Biological Evaluation of NH(2)-Sulfonyl Oseltamivir Analogues as Influenza Neuraminidase Inhibitors
A series of NH(2)-sulfonyl oseltamivir analogues were designed, synthesized, and their inhibitory activities against neuraminidase from H5N1 subtype evaluated. The results indicated that the IC(50) value of compound 4a, an oseltamivir analogue via methyl sulfonylation of C5-NH(2), was 3.50 μM. Molec...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600469/ https://www.ncbi.nlm.nih.gov/pubmed/31185617 http://dx.doi.org/10.3390/molecules24112176 |