CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of Tripterygium wilfordii

Celastrol and triptolide, as the two main bio-activity ingredients in Tripterygium wilfordii, have wide anticancer pharmacological potency, as well as anti-inflammatory and immunosuppression effects. However, they have potential hepatotoxicity and underlying mechanisms of them-induced toxicity media...

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Detalles Bibliográficos
Autores principales: Jin, Chunhuan, Wu, Zijun, Wang, Lili, Kanai, Yoshikatsu, He, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600472/
https://www.ncbi.nlm.nih.gov/pubmed/31181731
http://dx.doi.org/10.3390/molecules24112162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600472/
https://www.ncbi.nlm.nih.gov/pubmed/31181731
http://dx.doi.org/10.3390/molecules24112162

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