Quantitative Structure–Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity

Small-molecule compounds that have promising activity against macromolecular targets from Trypanosoma cruzi occasionally fail when tested in whole-cell phenotypic assays. This outcome can be attributed to many factors, including inadequate physicochemical and pharmacokinetic properties. Unsuitable p...

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Detalles Bibliográficos
Autores principales: de Souza, Anacleto S., Ferreira, Leonardo L. G., de Oliveira, Aldo S., Andricopulo, Adriano D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600563/
https://www.ncbi.nlm.nih.gov/pubmed/31181717
http://dx.doi.org/10.3390/ijms20112801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600563/
https://www.ncbi.nlm.nih.gov/pubmed/31181717
http://dx.doi.org/10.3390/ijms20112801

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