IDH1(R132H) Causes Resistance to HDAC Inhibitors by Increasing NANOG in Glioblastoma Cells

The R132H mutation in isocitrate dehydrogenase 1 (IDH1(R132H)) is commonly observed and associated with better survival in glioblastoma multiforme (GBM), a malignant brain tumor. However, the functional role of IDH1(R132H) as a molecular target for GBM treatment is not completely understood. In this...

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Detalles Bibliográficos
Autores principales: Kim, Geon-Hee, Choi, So Young, Oh, Taek-In, Kan, Sang-Yeon, Kang, Hyeji, Lee, Sujin, Oh, Taerim, Ko, Hyun Myung, Lim, Ji-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600637/
https://www.ncbi.nlm.nih.gov/pubmed/31151327
http://dx.doi.org/10.3390/ijms20112679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600637/
https://www.ncbi.nlm.nih.gov/pubmed/31151327
http://dx.doi.org/10.3390/ijms20112679

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