Human GBP1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis

The guanylate binding protein (GBP) family of interferon‐inducible GTPases promotes antimicrobial immunity and cell death. During bacterial infection, multiple mouse Gbps, human GBP2, and GBP5 support the activation of caspase‐1‐containing inflammasome complexes or caspase‐4 which trigger pyroptosis...

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Detalles Bibliográficos
Autores principales: Fisch, Daniel, Bando, Hironori, Clough, Barbara, Hornung, Veit, Yamamoto, Masahiro, Shenoy, Avinash R, Frickel, Eva‐Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600649/
https://www.ncbi.nlm.nih.gov/pubmed/31268602
http://dx.doi.org/10.15252/embj.2018100926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600649/
https://www.ncbi.nlm.nih.gov/pubmed/31268602
http://dx.doi.org/10.15252/embj.2018100926

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