Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent Escherichia coli ClpP Inhibitors

The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental processes, as well as virulence. Therefore, ClpP is considered as a potential drug target in Gram-positive and Gram-negative bacteria. In th...

Descripción completa

Detalles Bibliográficos
Autores principales: Sassetti, Elisa, Durante Cruz, Cristina, Tammela, Päivi, Winterhalter, Mathias, Augustyns, Koen, Gribbon, Philip, Windshügel, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600665/
https://www.ncbi.nlm.nih.gov/pubmed/31159170
http://dx.doi.org/10.3390/ijms20112686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600665/
https://www.ncbi.nlm.nih.gov/pubmed/31159170
http://dx.doi.org/10.3390/ijms20112686

Ejemplares similares