Exploratory locomotion, a predictor of addiction vulnerability, is oligogenic in rats selected for this phenotype

Artificially selected model organisms can reveal hidden features of the genetic architecture of the complex disorders that they model. Addictions are disease phenotypes caused by different intermediate phenotypes and pathways and thereby are potentially highly polygenic. High responder (bHR) and low...

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Detalles Bibliográficos
Autores principales: Zhou, Zhifeng, Blandino, Peter, Yuan, Qiaoping, Shen, Pei-Hong, Hodgkinson, Colin A., Virkkunen, Matti, Watson, Stanley J., Akil, Huda, Goldman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600920/
https://www.ncbi.nlm.nih.gov/pubmed/31182603
http://dx.doi.org/10.1073/pnas.1820410116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600920/
https://www.ncbi.nlm.nih.gov/pubmed/31182603
http://dx.doi.org/10.1073/pnas.1820410116

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