Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients

The emergence of treatment resistant sub-clones is a key feature of relapse in multiple myeloma. Therapeutic attempts to extend remission and prevent relapse include maximizing response and the use of maintenance therapy. We used whole exome sequencing to study the genetics of paired samples taken a...

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Detalles Bibliográficos
Autores principales: Jones, John R., Weinhold, Niels, Ashby, Cody, Walker, Brian A., Wardell, Chris, Pawlyn, Charlotte, Rasche, Leo, Melchor, Lorenzo, Cairns, David A., Gregory, Walter M., Johnson, David, Begum, Dil B., Ellis, Sidra, Sherborne, Amy L., Cook, Gordon, Kaiser, Martin F., Drayson, Mark T., Owen, Roger G., Jackson, Graham H., Davies, Faith E., Greaves, Mel, Morgan, Gareth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601103/
https://www.ncbi.nlm.nih.gov/pubmed/30733268
http://dx.doi.org/10.3324/haematol.2018.202200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601103/
https://www.ncbi.nlm.nih.gov/pubmed/30733268
http://dx.doi.org/10.3324/haematol.2018.202200

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