Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4

Our synthesis of the CDE ring fragment of pectenotoxin-4 utilised two key steps to make the complex bicyclic ketal unit: (i) a rhodium-catalysed vinyl group 1,4-addition as the major C–C bond forming step; (ii) a stereoselective Sharpless Asymmetric Dihydroxylation (SAD) of the resulting 1,1-disubst...

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Detalles Bibliográficos
Autores principales: Richardson, Melodie S. W., Tame, Christopher J., Poole, Darren L., Donohoe, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601420/
https://www.ncbi.nlm.nih.gov/pubmed/31341588
http://dx.doi.org/10.1039/c9sc01761e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601420/
https://www.ncbi.nlm.nih.gov/pubmed/31341588
http://dx.doi.org/10.1039/c9sc01761e

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