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Experiment stands corrected: accurate prediction of the aqueous pK(a) values of sulfonamide drugs using equilibrium bond lengths
We show here for the first time that strongly correlated linear relationships exist between equilibrium bond lengths of the sulfonamide group and aqueous pK(a) values. Models are constructed for three variants of the SO(2)NHR group: primary benzene sulfonamide derivatives (e.g. diuretic drugs furose...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601425/ https://www.ncbi.nlm.nih.gov/pubmed/31341593 http://dx.doi.org/10.1039/c9sc01818b |