Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset of cancers. One of the hallmarks of ALT cancer is the excessively clustered telomeres in promyelocytic leukemia (PML) bodies, represented as large bright telomere foci. Here,...

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Detalles Bibliográficos
Autores principales: Min, Jaewon, Wright, Woodring E., Shay, Jerry W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601508/
https://www.ncbi.nlm.nih.gov/pubmed/31171703
http://dx.doi.org/10.1101/gad.324905.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601508/
https://www.ncbi.nlm.nih.gov/pubmed/31171703
http://dx.doi.org/10.1101/gad.324905.119

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