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Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism

Prolonged cold exposure stimulates the recruitment of beige adipocytes within white adipose tissue. Beige adipocytes depend on mitochondrial oxidative phosphorylation to drive thermogenesis. The transcriptional mechanisms that promote remodeling in adipose tissue during the cold are not well underst...

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Detalles Bibliográficos
Autores principales: Pearson, Stephanie, Loft, Anne, Rajbhandari, Prashant, Simcox, Judith, Lee, Sanghoon, Tontonoz, Peter, Mandrup, Susanne, Villanueva, Claudio J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601513/
https://www.ncbi.nlm.nih.gov/pubmed/31123067
http://dx.doi.org/10.1101/gad.321059.118