Dedifferentiation by adenovirus E1A due to inactivation of Hippo pathway effectors YAP and TAZ

Adenovirus transformed cells have a dedifferentiated phenotype. Eliminating E1A in transformed human embryonic kidney cells derepressed ∼2600 genes, generating a gene expression profile closely resembling mesenchymal stem cells (MSCs). This was associated with a dramatic change in cell morphology fr...

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Detalles Bibliográficos
Autores principales: Zemke, Nathan R., Gou, Dawei, Berk, Arnold J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601516/
https://www.ncbi.nlm.nih.gov/pubmed/31171701
http://dx.doi.org/10.1101/gad.324814.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601516/
https://www.ncbi.nlm.nih.gov/pubmed/31171701
http://dx.doi.org/10.1101/gad.324814.119

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