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Dedifferentiation by adenovirus E1A due to inactivation of Hippo pathway effectors YAP and TAZ
Adenovirus transformed cells have a dedifferentiated phenotype. Eliminating E1A in transformed human embryonic kidney cells derepressed ∼2600 genes, generating a gene expression profile closely resembling mesenchymal stem cells (MSCs). This was associated with a dramatic change in cell morphology fr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601516/ https://www.ncbi.nlm.nih.gov/pubmed/31171701 http://dx.doi.org/10.1101/gad.324814.119 |