Cargando…
Important roles of CD32 in promoting suppression of IL-4 induced immune responses by a novel anti-IL-4Rα therapeutic antibody
Asthma is characterized by airway hyperresponsiveness and inflammation, as well as underlying structural changes to the airways. Interleukin-4 (IL-4) is a key T-helper type 2 (Th2) cytokine that plays important roles in the pathogenesis of atopic and eosinophilic asthma. We developed a novel humaniz...
Autores principales: | Zhao, Jie, Jiang, Liangfeng, Deng, Lan, Xu, Wei, Cao, Yang, Chen, Chen, Yang, Yan, Wu, Huiling, Huang, Yuping, Zhu, Zhenping, Huang, Haomin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601543/ https://www.ncbi.nlm.nih.gov/pubmed/30950681 http://dx.doi.org/10.1080/19420862.2019.1601985 |
Ejemplares similares
-
Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation
por: Le Floc’h, Audrey, et al.
Publicado: (2020) -
IL-32 and IL-34 in hepatocellular carcinoma
por: Si, Yang, et al.
Publicado: (2022) -
IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin
por: Prout, Melanie Sarah, et al.
Publicado: (2018) -
Anti CD4 antibodies directly suppress TNF-α production in human Th1 T-cell clones but not IL-4 production in Th2 clones
por: Tschiedel, S, et al.
Publicado: (2003) -
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4(+) T cells
por: Dienz, Oliver, et al.
Publicado: (2009)