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The impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry

Protein therapeutic higher order structure (HOS) is a quality attribute that can be assessed to help predict shelf life. To model product shelf-life values, possible sample-dependent pathways of degradation that may affect drug efficacy or safety need to be evaluated. As changes in drug thermal stab...

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Detalles Bibliográficos
Autores principales: Kerr, Richard A., Keire, David A., Ye, Hongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601562/
https://www.ncbi.nlm.nih.gov/pubmed/30913973
http://dx.doi.org/10.1080/19420862.2019.1599632