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Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells

Cul4b-null (Cul4b(Δ/)Y) mice undergo growth arrest and degeneration during the early embryonic stages and die at E9.5. The pathogenic causes of this lethality remain incompletely characterized. However, it has been hypothesized that the loss of Cul4b function in extraembryonic tissues plays a key ro...

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Detalles Bibliográficos
Autores principales: Chen, Chun-Yu, Yu, I-Shing, Pai, Chen-Hsueh, Lin, Chien-Yu, Lin, Shu-Rung, Chen, You-Tzung, Lin, Shu-Wha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602292/
https://www.ncbi.nlm.nih.gov/pubmed/31260508
http://dx.doi.org/10.1371/journal.pone.0219221