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Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells
Cul4b-null (Cul4b(Δ/)Y) mice undergo growth arrest and degeneration during the early embryonic stages and die at E9.5. The pathogenic causes of this lethality remain incompletely characterized. However, it has been hypothesized that the loss of Cul4b function in extraembryonic tissues plays a key ro...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602292/ https://www.ncbi.nlm.nih.gov/pubmed/31260508 http://dx.doi.org/10.1371/journal.pone.0219221 |