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Retinoic acid and arsenic trioxide induce lasting differentiation and demethylation of target genes in APL cells
Acute promyelocytic leukemia (APL) is characterized by arrested differentiation of promyelocytes. Patients treated with all-trans retinoic acid (ATRA) alone experience relapse, while patients treated with ATRA and arsenic trioxide (ATO) are often relapse-free. This suggests sustained changes have be...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602962/ https://www.ncbi.nlm.nih.gov/pubmed/31263158 http://dx.doi.org/10.1038/s41598-019-45982-7 |