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Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism

Numerous studies suggest that the increased activity of p38MAPK plays an important role in the abnormal immune and inflammatory response observed in the course of neurodegenerative diseases such as Alzheimer's disease. On the other hand, high levels of p38MAPK are present in the brain during no...

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Detalles Bibliográficos
Autores principales: Martín-Segura, Adrián, Casadomé-Perales, Álvaro, Fazzari, Pietro, Mas, José Manuel, Artigas, Laura, Valls, Raquel, Nebreda, Angel R., Dotti, Carlos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603139/
https://www.ncbi.nlm.nih.gov/pubmed/31293510
http://dx.doi.org/10.3389/fneur.2019.00675