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Mutations in the Global Transcription Factor CRP/CAP: Insights from Experimental Evolution and Deep Sequencing

The Escherichia coli cyclic AMP receptor protein (CRP or catabolite activator protein, CAP) provides a textbook example of bacterial transcriptional regulation and is one of the best studied transcription factors in biology. For almost five decades a large number of mutants, evolved in vivo or engin...

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Detalles Bibliográficos
Autores principales: Frendorf, Pernille Ott, Lauritsen, Ida, Sekowska, Agnieszka, Danchin, Antoine, Nørholm, Morten H.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603298/
https://www.ncbi.nlm.nih.gov/pubmed/31303977
http://dx.doi.org/10.1016/j.csbj.2019.05.009