The Anti-mycobacterial Activity of a Diterpenoid-Like Molecule Operates Through Nitrogen and Amino Acid Starvation

A library of 14 minimally cytotoxic diterpenoid-like compounds (CC(50) > 70 μM on HepG2 human liver cells) was screened against Mycobacterium smegmatis, Staphylococcus aureus, and Escherichia coli to determine antimicrobial activity. Some compounds with a phenethyl alcohol (PE) core substituted w...

Descripción completa

Detalles Bibliográficos
Autores principales: Crusco, Alessandra, Baptista, Rafael, Bhowmick, Sumana, Beckmann, Manfred, Mur, Luis A. J., Westwell, Andrew D., Hoffmann, Karl F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603307/
https://www.ncbi.nlm.nih.gov/pubmed/31293560
http://dx.doi.org/10.3389/fmicb.2019.01444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603307/
https://www.ncbi.nlm.nih.gov/pubmed/31293560
http://dx.doi.org/10.3389/fmicb.2019.01444

Ejemplares similares