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The Anti-mycobacterial Activity of a Diterpenoid-Like Molecule Operates Through Nitrogen and Amino Acid Starvation

A library of 14 minimally cytotoxic diterpenoid-like compounds (CC(50) > 70 μM on HepG2 human liver cells) was screened against Mycobacterium smegmatis, Staphylococcus aureus, and Escherichia coli to determine antimicrobial activity. Some compounds with a phenethyl alcohol (PE) core substituted w...

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Detalles Bibliográficos
Autores principales:	Crusco, Alessandra, Baptista, Rafael, Bhowmick, Sumana, Beckmann, Manfred, Mur, Luis A. J., Westwell, Andrew D., Hoffmann, Karl F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603307/ https://www.ncbi.nlm.nih.gov/pubmed/31293560 http://dx.doi.org/10.3389/fmicb.2019.01444

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