Ammonia sensitive SLC4A11 mitochondrial uncoupling reduces glutamine induced oxidative stress

SLC4A11 is a NH(3) sensitive membrane transporter with H(+) channel-like properties that facilitates Glutamine catabolism in Human and Mouse corneal endothelium (CE). Loss of SLC4A11 activity induces oxidative stress and cell death, resulting in Congenital Hereditary Endothelial Dystrophy (CHED) wit...

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Detalles Bibliográficos
Autores principales: Ogando, Diego G., Choi, Moonjung, Shyam, Rajalekshmy, Li, Shimin, Bonanno, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604051/
https://www.ncbi.nlm.nih.gov/pubmed/31254733
http://dx.doi.org/10.1016/j.redox.2019.101260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604051/
https://www.ncbi.nlm.nih.gov/pubmed/31254733
http://dx.doi.org/10.1016/j.redox.2019.101260

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