BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

BACKGROUND: Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding acetylated lysine residues. Targeted displac...

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Detalles Bibliográficos
Autores principales: Khoueiry, P., Ward Gahlawat, A., Petretich, M., Michon, A. M., Simola, D., Lam, E., Furlong, E. E., Benes, V., Dawson, M. A., Prinjha, R. K., Drewes, G., Grandi, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604197/
https://www.ncbi.nlm.nih.gov/pubmed/31266503
http://dx.doi.org/10.1186/s13072-019-0286-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604197/
https://www.ncbi.nlm.nih.gov/pubmed/31266503
http://dx.doi.org/10.1186/s13072-019-0286-5

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