BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

BACKGROUND: Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding acetylated lysine residues. Targeted displac...

Descripción completa

Detalles Bibliográficos
Autores principales: Khoueiry, P., Ward Gahlawat, A., Petretich, M., Michon, A. M., Simola, D., Lam, E., Furlong, E. E., Benes, V., Dawson, M. A., Prinjha, R. K., Drewes, G., Grandi, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604197/
https://www.ncbi.nlm.nih.gov/pubmed/31266503
http://dx.doi.org/10.1186/s13072-019-0286-5

Ejemplares similares

Ejemplares similares